A provider has ordered oral voriconazole (Vfend) for a patient who has a systemic fungal infection. The nurse obtains a medication history and learns that the patient takes phenobarbital for seizures
The nurse will contact the provider to discuss which possibility?
a. Administering intravenous voriconazole
b. Reducing the dose of phenobarbital
c. Reducing the dose of voriconazole
d. Using a different antifungal agent
ANS: D
Voriconazole can interact with many drugs. It should not be combined with drugs that are powerful P450 inhibitors, including phenobarbital, because these can reduce the levels of voriconazole. Administering the voriconazole IV will not increase the serum level. It is not correct to reduce the dose of either drug.
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