The release of lytic granules from cytotoxic T cells is aimed specifically at infected target cells while preserving the integrity of neighboring, uninfected cells. This is best explained by the observation that _____
a. only target cells bearing appropriate peptide:MHC class I complexes are susceptible to necrosis
b. redistribution of lytic granules in the T cell delivers them to confined areas on the target cell in contact with the T cell
c. regulatory T cells deliver survival signals to uninfected neighboring cells that renders them resistant to cytotoxins
d. the amount of cytotoxins in a given cytotoxic T cell is so limited that only the cell closest to the T cell will succumb to the effects of perforin and granzyme
e. uninfected cells are highly resistant to the effects of cytotoxins.
B
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Fill in the blank(s) with correct word