What sign/symptom is a major clinical manifestation of rheumatic fever (RF)?
a. Fever
b. Polyarthritis
c. Osler nodes
d. Janeway spots
ANS: B
Polyarthritis, which is swollen, hot, red, and painful joints, is a major clinical manifestation. The affected joints will change every 1 or 2 days. The large joints are primarily affected. Fever is considered a minor manifestation of RF. Osler nodes and Janeway spots are characteristic of bacterial endocarditis.
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