You are working in a research lab on the organism Drosophila melanogaster and you have been given
the job of determining the relative positions of three linked genes for your undergraduate research
project. A graduate student in the lab tells you that gene a is 5.0 centimorgans from gene b, and that
gene c is 2.7 centimorgans from gene b. What should you do to finish mapping these three genes?
What are the likely results that may occur, and how would you interpret such results?
What will be an ideal response?
To complete this task, one should perform crosses that will allow determination of the recombination
frequency between gene a and gene c. The recombination frequency will give the map distance
between genes a and c. There are two likely outcomes: an a-c map distance of about 2.3 centimorgans
and an a-c map distance of about 7.7 centimorgans. The results may not be exactly these values, but
they should be close to one or the other of them. A result of close to 2.3 centimorgans would indicate
that gene c is between genes a and b, while a result of close to 7.7 centimorgans would indicate that
gene b is between genes a and c.
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