Mutations in the cardiac ryanodine receptor have been associated with cardiac arrhythmias
Specifically, a mutation in the cardiac ryanodine receptor that increases Ca++ efflux from the SR promotes the development of delayed afterdepolarizations by:
A. decreasing the activity of calcineurin
B. increasing Ca++ efflux through the Na+-Ca++ antiporter
C. increasing mitochondrial Ca++ uptake
D. decreasing actin-myosin interactions
E. increasing the activity of K+ channels
ANS: B
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