Which of the following provides a negative feedback for heme synthesis, thus helping to control, by decreasing, its synthesis?
a. Concentration of heme in the developing RBC
b. Concentration of hemoglobin in blood
c. Concentration of globin chain in the developing RBC
d. Number of RBCs in circulation
ANS: A
As the concentration of heme increases in the developing RBC, it acts as a negative feedback to decrease further synthesis of heme. This helps control its rate of production.
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