Suppose there is a mutation in a laminin-binding integrin gene that causes a loss of function in the cytoplasmic domains of the integrin. Which of the following would you expect to observe as a result of this mutation?
A. The integrin would be unable to signal the
cytoplasm when it had bound to laminin.
B. The integrin would function normally
because the cytoplasmic domain is not
responsible for binding to laminin.
C. The strength of tissues would be
decreased because the integrin could no
longer associate with microfilaments in
adherens junctions.
D. Cell adhesion to laminin would decrease,
but laminin-meditated gene expression would
remain the same.
A
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