Which combination of antiretroviral drugs would the nurse be most likely to administer in a patient when antiviral drug resistance testing is not available?

A) Ritonavir-boosted protease inhibitors (RTV-boosted PIs) and nucleoside reverse transcriptase inhibitors (NRTIs)
B) Nonnucleoside reverse transcriptase inhibitors (NNRTIs) and NRTIs
C) Protease inhibitors and fusion inhibitors
D) Early inhibitors and integrase strand transfer inhibitors (INSTIs)


A) Ritonavir-boosted protease inhibitors (RTV-boosted PIs) and nucleoside reverse transcriptase inhibitors (NRTIs)

Explanation: A) To guide the choice of medications, treatment of individuals who have early-stage HIV infection should be preceded by genotypic antiviral resistance testing. When genotypic antiviral drug resistance testing is unavailable, HAART still may be initiated. Resistance to ritonavir (RTV)-boosted protease inhibitors typically develops slowly, and NRTIs are not prone to clinically significant TDR. As such, a combination of RTV-boosted PIs and NRTIs is recommended for individuals who do not undergo genotypic antiviral drug resistance testing.
B) To guide the choice of medications, treatment of individuals who have early-stage HIV infection should be preceded by genotypic antiviral resistance testing. When genotypic antiviral drug resistance testing is unavailable, HAART still may be initiated. Resistance to ritonavir (RTV)-boosted protease inhibitors typically develops slowly, and NRTIs are not prone to clinically significant TDR. As such, a combination of RTV-boosted PIs and NRTIs is recommended for individuals who do not undergo genotypic antiviral drug resistance testing.
C) To guide the choice of medications, treatment of individuals who have early-stage HIV infection should be preceded by genotypic antiviral resistance testing. When genotypic antiviral drug resistance testing is unavailable, HAART still may be initiated. Resistance to ritonavir (RTV)-boosted protease inhibitors typically develops slowly, and NRTIs are not prone to clinically significant TDR. As such, a combination of RTV-boosted PIs and NRTIs is recommended for individuals who do not undergo genotypic antiviral drug resistance testing.
D) To guide the choice of medications, treatment of individuals who have early-stage HIV infection should be preceded by genotypic antiviral resistance testing. When genotypic antiviral drug resistance testing is unavailable, HAART still may be initiated. Resistance to ritonavir (RTV)-boosted protease inhibitors typically develops slowly, and NRTIs are not prone to clinically significant TDR. As such, a combination of RTV-boosted PIs and NRTIs is recommended for individuals who do not undergo genotypic antiviral drug resistance testing.

Nursing

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