Discuss why percutaneous injection is generally preferred to epicutaneous or
intradermal testing for type I hypersensitivities.
What will be an ideal response
Tests for type I hypersensitivities must introduce suspected allergens into body sites that have mast cells. Since the
skin is rich in mast cells and is readily accessible, skin testing for type I hypersensitivities has been used extensively.
Epicutaneous or patch testing does not deliver sufficient antigens to the mast cells for good response, and
intradermal testing is dangerous because it could introduce the allergen systemically and cause anaphylaxis.
Correctly done percutaneous introduction of the allergen by scratches or pricks into the skin accesses mast cells
without inducing a systemic reaction.
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