An older client has had an instance of drug toxicity and asks why this happens, since the client has been on this medication for years at the same dose. What response by the nurse is best?
a. "Changes in your liver cause drugs to be metabolized differently."
b. "Perhaps you don't need as high a dose of the drug as before."
c. "Stomach muscles atrophy with age and you digest more slowly."
d. "Your body probably can't tolerate as much medication anymore."
ANS: A
Decreased liver enzyme activity depresses drug metabolism, which leads to accumulation of drugsâ€"possibly to toxic levels. The other options do not accurately explain this age-related change.
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