The nurse checks a newly ordered medication and finds it to be 92% protein bound. How much of the medication will be readily available to the client once the nurse administers the medication?
1. 100%.
2. 8%.
3. 50%.
4. 92%.
Correct Answer: 2
Rationale 1: If 100% of the drug were available to the client, none of it would be protein bound.
Rationale 2: The percentage of drug that is unbound is free and able to reach target tissue. If a drug is 92% protein bound, then 8% is free and available to tissues.
Rationale 3: If 50% of the drug is available to the client, then 50% is protein bound.
Rationale 4: The percentage of drug that is unbound is free and able to reach target tissue.
Global Rationale: The percentage of drug that is unbound is free and able to reach target tissue. If a drug is 92% protein bound, then 8% is free and available to tissues. If 100% of the drug were available to the client, none of it would be protein bound. If 50% of the drug is available to the client, then 50% is protein bound. The percentage of drug that is unbound is free and able to reach target tissue.
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