Dopamine agonists have been linked with which adverse effects in patients with Parkinson's disease?
a. Oculogyric crisis
b. Tardive dyskinesia
c. Sudden sleep events
d. Akathisia
ANS: C
Sleep episodes have been reported with the dopamine agonists bromocriptine, pergolide, pramipexole, and ropinirole. These are described as "sleep attacks," including daytime sleep. Oculogyric crisis is an adverse effect of neuroleptic drugs such as phenothiazines.
Tardive dyskinesia is a dystonic adverse effect of neuroleptic drugs such as phenothiazines. Akathisia, associated with neuroleptic drugs used in the treatment of mental disorders, is characterized by motor restlessness accompanied by increased nervous or restless movement. The syndrome may also occur when anti Parkinson drugs are reduced or discontinued.
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