An infant with recent seizures is being treated in the neonatal intensive care unit with phenytoin (Dilantin). The infant's low plasma protein levels during the first year of life have what consequence?
A) The infant may have an unpredictable drug response.
B) The infant may have an increased risk of toxicity.
C) The infant may experience impaired elimination of the drug.
D) The infant will have an increased rate of drug metabolism.
B
Feedback:
In infants, immature liver function leads to very low plasma protein levels, which limit the amount of protein binding by drugs. Consequently, the serum concentrations of highly protein-bound drugs may be higher, and toxicity may occur. This is not a result of differences in elimination or increased metabolism.
You might also like to view...
The nurse is examining a 3-year-old boy with acute otitis media who has a mild earache and a temperature of 38.5ºC. Which of the following actions will be taken?
A) Obtain a culture of the middle ear fluid. B) Instruct the parents to watch for worsening symptoms. C) Administer antibiotics. D) Administer antivirals.
A client is scheduled for thyroidectomy as part of his treatment for thyroid cancer. Which of the following aspects of care will be conducted in the receiving room of the operating department?
A) Preoperative medications are administered. B) The client is intubated and anesthetized. C) The client education process is begun. D) The client is assessed for suitability as a surgical candidate.
To prevent nipple trauma, the mother should be taught to:
a. Limit the feeding time to less than 5 minutes. b. Position the infant so the nipple is far back in the mouth. c. Assess the nipples before each feeding. d. Wash the nipples daily with mild soap and water.
The nurse is conducting a staff in-service on inherited childhood blood disorders. Which statement describes severe combined immunodeficiency syndrome (SCIDS)?
a. There is a deficit in both the humoral and cellular immunity with this disease. b. Production of red blood cells is affected with this disease. c. Adult hemoglobin is replaced by abnormal hemoglobin in this disease. d. There is a deficiency of T and B lymphocyte production with this disease.