Which of the following is a typical finding in paroxysmal nocturnal hemoglobinuria?
a. Hemosiderin in urine sediment
b. Normal levels of decay accelerating factor (CD55)
c. Hemolysis when blood is alkaline
d. Elevated white cells and platelets
ANS: A
Hemosiderin is present and a useful diagnostic tool in paroxysmal nocturnal hemoglobinuria. Levels of CD55 are decreased in paroxysmal nocturnal hemoglobinuria. Hemolysis occurs when blood is acidic, and platelets and white cells are usually decreased so that the patient is pancytopenic.
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