In geriatric patients, the percentage of body fat is increased. What are the pharmacologic implications of this physiologic change?
1. A lipid-soluble medication will be eliminated more quickly and not work as well.
2. A lipid-soluble medication will accumulate in fat tissue and its duration of action may be prolonged.
3. Absorption of lipid-soluble drugs is impaired in older adults.
4. The bioavailability of the lipid-soluble drug will be increased in older adults.
ANS: 2
RAT: Lipid medications will accumulate in fatty tissues prolonging the half-lives of these drugs.
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