The nurse is providing drug teaching about quinidine in preparation for the patient's discharge. The nurse discusses drug–food interactions and advises the patient to drink what?
A) Apple juice
B) Grapefruit juice
C) Milk
D) Orange juice
A
Feedback:
Apple juice would be the best choice. Quinidine requires a slightly acidic urine (normal state) for excretion. Patients receiving quinidine should avoid foods that alkalinize the urine (e.g., citrus juices, vegetables, antacids, milk products), which could lead to increased quinidine levels and toxicity. Grapefruit juice has been shown to interfere with the metabolism of quinidine, leading to increased serum levels and toxic effects; this combination should be avoided.
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