Concurrent use of azathioprine and an ACE inhibitor could result in which adverse effect?
1. Flulike symptoms
2. Hypercholesteremia
3. Hematuria
4. Anemia and leukopenia
Correct Answer: 4
Rationale 1: Flulike symptoms do not occur with azathioprine and an ACE inhibitor.
Rationale 2: Hypercholesteremia is not an adverse effect of these two agents.
Rationale 3: Concurrent use with ACE inhibitors and azathioprine does not result in hematuria.
Rationale 4: Concurrent use of azathioprine and an ACE inhibitor could result in anemia and severe leukopenia.
Global Rationale: The use of angiotensin-converting enzyme (ACE) inhibitors with azathioprine may induce anemia and severe leukopenia. Flulike symptoms, hypercholesteremia, and hematuria are not adverse effects of concurrent use of these two drugs.
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