The client has been diagnosed with several chronic illnesses and takes medications for these conditions throughout each day. Which of the following client issues may affect the bioavailability of the client's medications? (Select all that apply

Question

) 1. Hypoactive bowel sounds in all four quadrants
2. Complaints of nausea after eating
3. The client has been diagnosed with chronic pancreatitis
4. The client takes omeprazole for GERD (gastroesophageal reflux disease)
5. The client has a urinary tract infection

Answer 1

1, 2, 3, 4
Rationale: Hypoactive bowel sounds may indicate the client has a decreased rate of peristalsis, which negatively influences bioavailability of medications. Complaints of nausea after eating can indicate the client has a reduced rate of gastric emptying, which can diminish the bioavailability of medications. A client with chronic pancreatitis may not be secreting digestive enzymes to help break down the medication. This negatively impacts bioavailability. The client with gastroesophageal reflux disease who takes a proton pump inhibitor has an increased pH in their stomach. The increased pH decreases bioavailability of medications. Medications are broken down more quickly with more acidic gastric secretions. The client's urinary tract infection will not impact bioavailability. However, if the client had a problem with their liver, this may impact their ability to produce bile and this would negatively impact medication bioavailability.