A client has had difficulty achieving glycemic control with oral medications for Type 2 diabetes. Frustrated, the client says, "Isn't there some way to predict how my body will respond?" What is the nurse's best response?

1. "No one has studied that."
2. "Finding the correct medication and dose is a trial-and-error method."
3. "Some studies have been done, but they are not large enough to guide our treatment decisions."
4. "We are many years from having that kind of help from genetic studies."


3
Rationale 1: Genetic studies have determined that a variation of TCF7L2 predicts response to sulfonylurea medications.
Rationale 2: Using the term "trial-and-error" is not therapeutic.
Rationale 3: Variations in TCF7L2 genotypes predict response to sulfonylurea medications, but the study is not large enough to guide treatment.
Rationale 4: The studies do exist but are not large enough to guide treatment. Hopefully, this kind of guidance will exist before "many years" have passed.

Nursing

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