Why does the initial rate of an enzymatic reaction eventually plateau at a maximal velocity even though the concentration of the substrate continues to be increased?

A) Enzymes are denatured following action on a substrate.
B) High concentrations of substrate inhibit movement of the substrate to available enzymes.
C) The enzyme available in the solution has been consumed.
D) The enzyme is saturated and unable to bind substrate at a higher rate.


D

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