Why does a patient who is taking drugs for thyroid suppression continue to have symptoms of hyperthyroidism for 3 weeks (or longer) after drug therapy is started?
a. Thyroid hormones are stored and thyroid suppressing drugs only stop the synthe-sis of new hormones.
b. At first, the patient's metabolism is so high that the thyroid cells continue to syn-thesize thyroid hormones.
c. The activity of the intestinal tract is increased and the drug is eliminated before complete suppression can occur.
d. The side effects of thyroid suppression drugs are so uncomfortable that most pa-tients do not take the full dose of the drug that is needed to prevent further hor-mone secretion.
A
Thyroid-suppressing drugs enter the thyroid gland and combine with the enzyme responsible for connecting iodine (iodide) with tyrosine to make active thyroid hormones, preventing further thyroid hormone synthesis. These drugs do not affect the hormones already formed and stored in the thyroid gland, so it may take as long as 3 or 4 weeks for the person to use up all the thyroid hormones made before the drug was started. Until that time, the person continues to have symp-toms of hyperthyroidism.
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