Duchenne muscular dystrophy is a recessive disorder resulting in a wasting away of the muscles. How would you design a study to determine if the disorder is X-linked or autosomal? How would you be able to determine if it is X-linked or autosomal?

What will be an ideal response?


The study would analyze the inheritance patterns of a family through many generations, using a pedigree. If phenylkenonuria is X-linked, then more males than females will be affected, an affected son can have parents who are normal, and for a female to have it her father must also have it and her mother must have the disorder or be a carrier. It can also skip generations from grandfather to grandson. If the disorder is autosomal, both males and females are affected equally.

Biology & Microbiology

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