How are serotonergic agonists a possible treatment for obesity?
What will be an ideal response?
> because serotonin agonists have been shown to reduce food consumption in both human and nonhuman subjects, they have considerable potential in the treatment of obesity
> serotonin agonists seem to act by a mechanism different from that of leptin and insulin, which produce long-term satiety signals based on fat stores
> serotonin agonists seem to increase short-term satiety signals associated with the consumption of a meal
>> have been found in various studies of obese patients to reduce the urge to eat high-calorie foods, the consumption of fat, the size of meals, the number of between-meal snacks, and bingeing
> pulled from the market because use was found to be associated with heart disease in a small but significant number of users
>> only approved serotonin agonist is lorcaserin (however, the efficacy of lorcaserin is only modest)
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