Parents arrive to the clinic with their 5-year-old child and inform the nurse the child has just been diagnosed with sickle cell disease. The parents ask the nurse how this could have happened and which one of them is the carrier
What is the best response by the nurse? A) "Most likely, the father is the carrier of the gene."
B) "The trait is passed down through the mother."
C) "The child must inherit two defective genes, one from each parent."
D) "It is an acquired, not a hereditary disorder."
C
Feedback:
Sickle cell disease is a hereditary disorder. To manifest this disorder, a person must inherit two defective genes, one from each parent, in which case all the hemoglobin is inherently abnormal. If the person inherits only one gene, he or she carries sickle cell trait. The hemoglobin of those who have sickle cell trait is about 40% affected. The other distractors are incorrect due to these factors.
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