How does RISC recognize mRNAs for silencing?
A. Complementary base pairing allows the miRNA or siRNA and the mRNA to interact.
B. Binding occurs by chance as RISC contacts mRNAs in the cytoplasm.
C. The miRNA hairpin loop is a binding site for mRNA.
D. A protein component of RISC has a binding site for mRNA.
Answer: A
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