Xanthines are not as popular as they were 20 years ago. Why has this group of medications lost its popularity?
1. They have a slower onset.
2. They are related to caffeine.
3. They produce less effective bronchodilation.
4. They interact with a large number of other drugs.
Correct Answer: 4
Rationale 1: They have a slower onset is incorrect. The xanthines (theophylline, aminophylline) are chemically related to caffeine but have been replaced by safer, more effective drugs. Side effects such as nausea, vomiting, and CNS stimulation are relatively common; dysrhythmias might be observed at high doses, and there is a narrow margin of safety with theophylline because it reacts to a large number of other drugs.
Rationale 2: They are related to caffeine is incorrect because xanthines interact with a large number of drugs.
Rationale 3: They produce less effective bronchodilation is incorrect. The xanthines (theophylline, aminophylline) are chemically related to caffeine but have been replaced by safer, more effective drugs. Side effects such as nausea, vomiting, and CNS stimulation are relatively common; dysrhythmias might be observed at high doses, and there is a narrow margin of safety with theophylline because it reacts to a large number of other drugs.
Rationale 4: The xanthines (theophylline, aminophylline) are chemically related to caffeine but have been replaced by safer, more effective drugs. Side effects such as nausea, vomiting, and CNS stimulation are relatively common; dysrhythmias might be observed at high doses, and there is a narrow margin of safety with theophylline because it reacts to a large number of other drugs.
Global Rationale: The xanthines (theophylline, aminophylline) are chemically related to caffeine but have been replaced by safer, more effective drugs. Side effects such as nausea, vomiting, and CNS stimulation are relatively common; dysrhythmias might be observed at high doses, and there is a narrow margin of safety with theophylline because it reacts to a large number of other drugs. They are related to caffeine is incorrect because xanthenes interact with a large number of drugs.
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