A dysfunction of receptors for the protein hormone, leptin, can provoke:
a. Excessive phagocytosis by tissue macrophages
b. Immunoglobulin deficiency
c. Impaired synthesis of collagen
d. Obesity
e. Septic shock
ANS: D
The fat cell hormone, leptin, binds to receptors in the hypothalamus to regulate feeding and obe-sity. In its absence, as occurs in genetically obese mice, the hypothalamus does not restrain ap-petite and the excess of ingested calories is stored as fat. See 3-17.
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