If a bioactive drug undergoes a significant first pass metabolism and is administrated orally, the drug is more likely:
a. Absorbed through the GI tract, delivered to the liver through the portal vein, and inactivated by liver enzymes
b. Absorbed through the GI tract, delivered to the liver through the hepatic artery, and inactivated by liver enzymes
c. Absorbed through the GI tract, delivered to the liver through the hepatic vein, and inactivated by liver enzymes
d. Absorbed through the GI tract, delivered to the brain through the circle of Willis, and affecting the brain function
e. Absorbed through the GI tract, stored in the gallbladder and released in the small intestines to help digest food
Ans: a. Absorbed through the GI tract, delivered to the liver through the portal vein, and inactivated by liver enzymes
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