T-cell lymphocytes leave the bone marrow and travel to the thymus. If successful, they differentiate into which of the following cells? Select all that apply
A) CD4+ helper T cells
B) Epstein-Barr virus (EBV)
C) Hematopoietic stem cell
D) Kupffer cells
E) CD8+ cytotoxic T cells
Ans: A, E
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The body's lymphatic system consists of the lymphatic vessels, lymphoid tissue, and lymph nodes, thymus, and spleen. T lymphocytes leave the bone marrow as precursor T lymphocytes travel to the thymus, where they differentiate into CD4+ helper T cells and CD8+ cytotoxic T cells, after which many of them move to lymph nodes, where they undergo further proliferation. Infectious mononucleosis is a self-limiting lymphoproliferative disorder caused by the Epstein-Barr virus (EBV), a member of the herpesvirus family. Kupffer cells of the liver are not a component of the lymphatic system. The human T-cell lymphotropic virus (HTLV-1), which is endemic in the southwestern islands of Japan, has been associated with adult T-cell leukemia/lymphoma.
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