Consider a sample of 100 individuals sampled from a population in Hardy–Weinberg equilibrium that are gen-otyped at the single locus
Of these 100 individuals, 25 individuals are A1A1 homozygotes, 45 are A1A2 heterozygotes, and 30 are A2A2 homozygotes. Please list the observed and expected genotypic frequencies of this locus in this sample
What will be an ideal response?
ANS:
Observed genotype frequencies:
A1A1 = 25/100 = 0.25
A1A2 = 45/100 = 0.45
A2A2 = 30/100 = 0.30
Observed allele frequencies:
A1 = 0.25 + (0.45/2) = 0.475
A2 = 0.30 + (0.45/2) = 0.525
Expected genotype frequencies:
A1A1 = (0.475)2 = 0.23
A1A2 = 2(0.475)(0.525) = 0.50
A2A2 = (0.525)2 = 0.27
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