The nurse would explain that Augmentin is a combination drug containing the antibiotic amoxicillin and clavulanate, which is a(n):
clavulanate, which is a(n):
1. secondary antibiotic.
2. beta-lactamase inhibitor to prevent the excretion of penicillin.
3. anti-inflammatory to prevent allergic response.
4. antiviral to prevent superinfection.
Correct Answer: 2
Rationale 1: Clavulanate is not an antibiotic.
Rationale 2: Clavulanate prevents the action of beta-lactamase, which would decrease the life of the penicillin.
Rationale 3: Clavulanate is not an anti-inflammatory and would not prevent allergic responses.
Rationale 4: Clavulanate is not an antiviral and would not prevent superinfection.
Global Rationale: The fixed-dose combination of Augmentin combines amoxicillin with clavulanate, a beta-lactamase (penicillinase) inhibitor. By inhibiting penicillinase, these combined drugs allow a greater percentage of the aminopenicillin molecules to reach pathogens and affect cell wall synthesis. The beta-lactamase inhibitors are ineffective when used alone and therefore are always used in fixed combination formulations with other drugs.
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