Barbiturates were given to an older man with reduced kidney function, and he nearly died as a result. What was the most likely reason for this near-fatality?
A) Increased drug dosage
B) Increased kidney filtration
C) Increased biological half-life of the drug
D) Increased reabsorption of the drugs into the blood
C
Feedback:
When kidney function is reduced, the biological half-life can increase as much as 40% and increase the risk of adverse drug reactions. Reabsorption into the blood and kidney filtration is decreased in this patient, and there is no reason to think the dosage was increased.
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