The client receives zidovudine (Retrovir) for treatment of human immunodeficiency virus (HIV) infection. The nurse would increase assessment surveillance for which adverse reactions from this treatment?
1. Fatigue and generalized weakness
2. New onset headache
3. Constipation
4. Edema
5. Liver palpable on physical examination
1,2,5
Rationale 1: Fatigue and weakness are experienced by many clients taking zidovudine.
Rationale 2: Headache will occur in the majority of clients taking this medication.
Rationale 3: Diarrhea is a more expected adverse reaction.
Rationale 4: Edema is not an expected adverse reaction.
Rationale 5: Hepatomegaly can occur and may require dosage adjustments or discontinuation of this drug.
Global Rationale: Fatigue and weakness are experienced by many clients taking zidovudine. Headache will occur in the majority of clients taking this medication. Hepatomegaly can occur and may require dosage adjustments or discontinuation of this drug. Diarrhea is a more expected adverse reaction than constipation. Edema is not an expected adverse reaction.
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