Infants and children are especially at risk for adverse reactions to medications, including age-specific adverse reactions and ineffective treatment, for which of the following reasons?
a. Drug companies make less money on pediatric clients than on other ages, so they do less research on drugs for this age group.
b. Ethical constraints related to informed consent severely limit the amount of testing of most drugs used with the pediatric population.
c. Mothers are a powerful lobbying group in Congress, the Department of Health and Human Services, and the Food and Drug Administration.
d. The response to medications varies significantly among children of similar weights and heights.
B
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A Incorrect. Infants and children are especially at risk for adverse reactions to medications, but not primarily as a consequence of the fact that the drug companies make less money on pediatric clients than on other ages.
B Correct. Until recently children have been excluded from drug trials due to ethical constraints related to informed consent and research risks. Since most drugs have not been adequately tested in the pediatric population, there is a relative lack of information on drug safety and efficacy in infants and children. Consequently, infants and children are at risk for adverse reactions, including age-specific adverse reactions and ineffective treatment.
C Incorrect. Infants and children are especially at risk for adverse reactions to medications, but not primarily as a consequence of the fact that mothers are a powerful lobbying group.
D Incorrect. Infants and children are especially at risk for adverse reactions to medications, but not primarily as a consequence of the fact that the response to medications varies significantly among children of similar weights and heights.
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