In the context of drug interactions, identify the true statement about grapefruit juice.
A. Atorvastatin, lovastatin, and simvastatin are not affected by grapefruit juice.
B. Taking medication in the presence of grapefruit juice significantly reduces the bioavailability of the medication.
C. Grapefruit juice interacts only with drugs that are administered orally.
D. Grapefruit juice can significantly increase drug metabolism at the intestinal wall.
Answer: C
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