When the nurse understands that clozapine preferentially blocks dopamine receptors in the limbic
system rather than in the basal ganglia, the nurse will plan to assess the client for
a. seizures.
b. marked motor disturbances.
c. strong suicidal tendencies.
d. greatly increased appetite.
ANS: A
Clozapine has the potential for inducing convulsions in approximately 3% of clients. All clients
receiving this drug should be monitored for seizure activity. Option B: The blockade of dopamine
receptors in the basal ganglia is responsible for movement disorders associated with administration
of standard antipsychotics. Clozapine selectively targets the limbic system, which is not involved in
movement. Option C: Clozapine therapy is not associated with producing suicidal ideation. Option
D: Clozapine therapy is not associated with increased appetite.
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