Dentinogenesis imperfecta is a rare, autosomal, dominantly inherited disease of the teeth that occurs in about one in 8000 people (Witkop, 1957). The teeth are somewhat brown in color, and the crowns wear down rapidly

Assume that a male with dentinogenesis imperfecta and no family history of the disease marries a woman with normal teeth. What is the probability that
(a) their first child will have dentinogenesis imperfecta?
(b) their first two children will have dentinogenesis imperfecta?
(c) their first child will be a girl with dentinogenesis imperfecta?


(a) 1/2
(b) 1/2 Ɨ1/2 = 1/4
(c) 1/2 Ɨ 1/2 = 1/4

Biology & Microbiology

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