Many hormones are synthesized as preprohormones. A mutation in a preprohormone-encoding gene that changed the amino acid sequence of the signal peptide could result in:
A. inability of the hormone to be secreted
B. decreased circulating half-life of the hormone
C. secretion of a smaller hormone
D. inability of the hormone gene to be transcribed
E. reduced affinity of the hormone for its receptor
ANS: A
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