A client is being given two highly protein-bound drugs concurrently. What is most likely to be the result of this administration?
a. More free drug in circulation
b. Less free drug in circulation
c. More drug bound to protein
d. More drug excreted in the urine
ANS: A
When two highly protein-bound drugs are given concurrently, they compete for protein-binding sites, causing more free drug to be released into the circulation. Drug accumulation and possible drug toxicity can result.
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