A nurse is reading a journal article about psychoneuroimmunology. Which information would the nurse most likely find? Select all that apply
A) Neurotoxin's role in receptor site damage
B) Hypothalamic–pituitary–thyroid axis disruption
C) Static activity of natural killer cells in response to stress
D) Hypothalamic damage leading to immune dysfunction
E) Interruption in the typical circadian rhythm cycle
Ans: A, B, D
Psychoneuroimmunology addresses possible explanations for the development of psychiatric disorders based on the interaction of the neurologic, endocrine, and immune systems. Areas addressed include immune dysregulation caused by neurotoxins affecting the brain tissue at locations such as receptor sites; disruption of the hypothalamic–pituitary–thyroid axis feedback system; and immune system dysfunction resulting from damage to the hypothalamus, hippocampus, or pituitary gland. Another area being studied is the role of natural killer cell function, which shows that natural killer cell activity varies in response to many emotional, cognitive, and physiologic stressors.
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