What drives the bicarbonate buffer systems enormous ability to buffer acids?
a. The fact that H2CO3 is a strong buffer
b. The Henderson-Hasselbalch equation
c. The large amounts of 2,3-DPG in red blood cells
d. Ventilation continually removing CO2 from system
ANS: D
This allows HCO3– to continue buffering H+ as long as ventilation continues. Hypothetically, this buffering activity can continue until all body sources of HCO3– are used up in binding H+ (i.e., the aforementioned reaction is continually pulled to the left because ventilation continually re-moves CO2).
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