A nurse is reviewing information about a psychiatric medication that describes the amount of the drug that actually reaches systemic circulation unchanged. The nurse identifies this as which of the following?
A) First-pass effect
B) Bioavailability
C) Solubility
D) Biotransformation
Ans: B
Bioavailability describes the amount of a drug that actually reaches the systemic circulation unchanged. First-pass effect refers to the metabolism that a drug undergoes within the gastrointestinal wall or liver before reaching the rest of the body. Solubility refers to the ability of a medication to cross a membrane. Biotransformation or metabolism is the process by which a drug is altered and broken down into small substances known as metabolites.
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