Describe two ways in which the immunoglobulins acting as antigen receptors on the surface of a mast cell differ from the immunoglobulins acting as the antigen receptors on the surface of a B cell
What will be an ideal response?
(i) The immunoglobulin on a mast cell is an IgE antibody that has become bound to the mast cell's FcεRI receptor, whereas the immunoglobulin on a B cell is a transmembrane form made by the cell itself. (ii) A B cell might have any class of immunoglobulin on its surface, whereas mast cells have only IgE. (iii) IgE molecules of many different antigen specificities can be bound to the surface of an individual mast cell, whereas an individual B cell carries immunoglobulin molecules of only one specificity.
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