Which represents the correct order of the three stages of the natural history of disease?
A) Pathological onset, manifestation of clinical disease, presymptomatic
B) Presymptomatic, pathological onset, manifestation of clinical disease
C) Pathological onset, presymptomatic, manifestation of clinical disease
D) Manifestation of clinical disease, presymptomatic, pathological onset
Ans: C
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Epidemiologic research has established the natural history of most illnesses. This refers to the course of a disease or condition from the onset to resolution. It includes (1) the pathological onset stage, (2) the presymptomatic stage, and (3) the manifestation of clinical disease.
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