The nurse is preparing to administer felodipine to a hospitalized client. The nurse assesses the client for which disorders that may cause an increased risk for adverse effects associated with this medication due to its extended half-life?
1. Renal disease
2. Liver disease
3. Gastrointestinal disease
4. Cardiac disease
5. Pulmonary disease
Correct Answer: 1,2
Rationale 1: As drugs stay in the body for prolonged periods, the risk for long-term adverse effects increases. This can become particularly serious for clients with significant renal impairment; diminished metabolism and excretion will cause the plasma half-life of a drug to increase, and the concentration may reach toxic levels.
Rationale 2: As drugs stay in the body for prolonged periods, the risk for long-term adverse effects increases. This can become particularly serious for clients with significant hepatic impairment; diminished metabolism and excretion will cause the plasma half-life of a drug to increase, and the concentration may reach toxic levels.
Rationale 3: Gastrointestinal disease does not increase the risk of adverse drug effects.
Rationale 4: Cardiac disease does not increase the risk of adverse drugs effects.
Rationale 5: Pulmonary disease does not increase the risk of adverse drug effects.
Global Rationale: As drugs stay in the body for prolonged periods, the risk for long-term adverse effects increases. This can become particularly serious for clients with significant renal impairment; diminished metabolism and excretion will cause the plasma half-life of a drug to increase, and the concentration may reach toxic levels. Gastrointestinal disease does not increase the risk of adverse drug effects. Cardiac disease does not increase the risk of adverse drugs effects. Pulmonary disease does not increase the risk of adverse drug effects.
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