Which of the following is true of megakaryocytes as they mature?
a. Nucleus becomes polyploid
b. Cytoplasmic basophilia becomes more pronounced
c. Size decreases
d. Nucleoli become more prominent
ANS: A
As the megakaryocyte matures, it undergoes endomitosis. Deoxyribonucleic acid (DNA) synthesis normally proceeds to 8N, 16N, or 32N, but no cell division occurs. The nucleus is thus polyploid. Basophilia in the cytoplasm diminishes, but the cytoplasmic volume increases along with the nuclear size so that the cell becomes the largest cell in the bone marrow. The chromatin gradually clumps, and nucleoli become less prominent and eventually cannot be detected.
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