The nurse states that the development of an HIV vaccination has been unsuccessful due to the large size of the HIV genome, which has ______ base pairs and leads to the high mutation rate of the virus
Standard Text: Record your answer rounding to the nearest whole number.
Fill in the blank with the appropriate word.
Correct Answer: 10,000
Rationale : It is estimated that, given the size of the HIV genome at 10,000 base pairs, every possible mutation probably occurs at every nucleotide daily in an untreated client. These errors create huge numbers of genetic variants, or mutant strains, with new and different characteristics from the original. It is not unusual to find dozens of genetic variants of HIV replicating within the same client. Thus, vaccine development, and indeed antiretroviral therapy, is trying to hit a "moving target" that is changing its genetic makeup literally every minute.
Global Rationale: It is estimated that, given the size of the HIV genome at 10,000 base pairs, every possible mutation probably occurs at every nucleotide daily in an untreated client. These errors create huge numbers of genetic variants, or mutant strains, with new and different characteristics from the original. It is not unusual to find dozens of genetic variants of HIV replicating within the same client. Thus, vaccine development, and indeed antiretroviral therapy, is trying to hit a "moving target" that is changing its genetic makeup literally every minute.
You might also like to view...
A nurse educator is teaching a group of students about the traits of a mentally healthy individual. Which concepts provide information regarding psychological, emotional, and social health? Select all that apply
1. Behavior 2. Intrapersonal relationships 3. Gender 4. Age 5. Interpersonal relationships
What health promotion and lifestyle strategies will the nurse suggest to a patient with shift work disorder? Select all that apply
1. Avoid working excessive overtime. 2. Arrive to work as rested as possible. 3. Use caffeine to stay awake while driving home. 4. Exercise regularly, especially if job is sedentary. 5. Allow at least a 5 hour sleep period without interruption.
A pregnant client plans to deliver the baby at home. For which reason should the nurse emphasize that the newborn will need an injection of vitamin K after birth?
a. Newborn infants have insufficient vitamin K stores b. Breast milk does not contain an adequate supply of vitamin K c. Lack of vitamin K can result in bone formation issues after birth d. Only small amounts of vitamin K are innately inherited from the mother
Which disorder has been identified as an occupational health risk for agricultural workers?
a. Stroke b. Heart disease c. Diabetes d. Cancer