A patient suffers from upper airway edema. The disorder has occurred several times in last 3 months. The patient may have a deficiency in:
A) Red blood cells
B) C-1 esterase inhibitor
C) Cholesterol
D) Immunogammaglobulin A
Ans: B
Feedback: Hereditary angioneurotic edema results from the deficiency of C-1 esterase inhibitor, which opposes the release of inflammatory mediators. The clinical picture of this autosomal-dominant disorder includes recurrent attacks of edema formation in the subcutaneous tissue, gastrointestinal tract, and upper airway. Ataxia-telangiectasia is an autosomal-recessive neurodegenerative disorder that arises because of a defect on chromosome 11. In 40% of the patients with ataxia-telangiectasia, a selective IgA deficiency exists. The red blood cells and cholesterol are unaffected.
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