A pharmacist is teaching a group of nurse practitioners about the differences between pharmacokinetics among older adults and among younger clients
Which of the following teaching points best captures an aspect of drug therapy among older adults?
A)
"Your older patients are going to have higher serum concentrations of water-soluble drugs because of the patients' leaner body mass."
B)
"The absorption time of oral medications is going to be much longer because of decreased gastrointestinal motility in older adults."
C)
"Plasma concentrations of fat-soluble drugs can increase because older adults have less adipose tissue in which to store excess drug molecules."
D)
"Decreased renal and hepatic function contributes to accumulation of drugs in these organs."
Ans:
A
Feedback:
Lean body mass and lower water volumes result in higher plasma concentrations of water-soluble drugs. Absorption time does not decrease in older adults, and fat-soluble drugs can accumulate in their adipose tissue. Decreased renal and hepatic function results in reduced clearance but not accumulation in the kidneys and liver themselves.
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