During the first month to 24 months of age, the liver of the neonate is immature. While the liver is immature, medications metabolized by the liver have:
a. a shorter half-life c. a longer half-life
b. no half-life d. about the same half-life
C
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A Incorrect. During the first month to 24 months of age, the liver of the neonate is immature. While the liver is immature, medications metabolized by the liver have a longer half-life, not a shorter half-life.
B Incorrect. Not one medication lacks a half-life.
C Correct. Due to liver immaturity, the drug-metabolizing capacity of premature infants and neonates is low. Although liver function develops rapidly during the first few months after birth, complete maturation of hepatic enzyme activity is not reached until 1 to 2 years of age. During this time, drugs metabolized by the liver have a longer half-life and there is an increased risk of toxicity.
D Incorrect. During the first month to 24 months of age, the liver of the neonate is immature. While the liver is immature, medications metabolized by the liver have a longer half-life, not about the same half-life.
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